As of 30 April, three cases were reported in Ecuador. Predicting new cases is uncertain due to virus transmission dynamics and irregular border crossings, especially from Colombia and Peru, where outbreaks persist. Risk is higher in Amazonian provinces with 88% vaccination—below the 95% target recommended by the Ministry of Public Health. Low coverage has led to rapid spread before. Strengthening surveillance, vector control, and immunization is key to protecting vulnerable populations.